DACT3 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1709	100 μL

Catalog No. 50-198-1709 Supplier Bioss Supplier No. BS11837R

Description

Rabbit Polyclonal Antibody

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.

Specifications

• Antigen: DACT3
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: DACT3
• Gene Accession No.: Q96B18
• Gene Alias: Antagonist of beta-catenin Dapper homolog 3; Arginine-rich region 1 protein; dact 3; DACT3; Dapper antagonist of catenin 3; Dapper homolog 3; dapper homolog 3, antagonist of beta-catenin (xenopus); dapper, antagonist of beta-catenin, homolog 3; DAPPER3; dishevelled binding antagonist of beta catenin 3; dishevelled-binding antagonist of beta-catenin 3; EG666671; naa-3; RGD1563892; RRR1
• Gene Symbols: DACT3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human DACT3.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 147906
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG