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Invitrogen™ DAGLB Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA526331
Description
DAGLB Polyclonal Antibody for Western Blot, Flow
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. [UniProt].
Specifications
DAGLB | |
Polyclonal | |
Unconjugated | |
DAGLB | |
DAGLB; DAGLBETA; DGL-beta; diacylglycerol lipase beta; diacylglycerol lipase, beta; E330036I19Rik; KCCR13L; RGD1310193; sn1-specific diacylglycerol lipase beta | |
Rabbit | |
Antigen affinity chromatography, Protein A | |
RUO | |
221955, 231871 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Flow Cytometry, Western Blot | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q8NCG7, Q91WC9 | |
DAGLB | |
KLH conjugated synthetic peptide between 491-518 amino acids from the central region of human DAGLB. | |
400 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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