Invitrogen™ DAGLB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567047

Catalog No. PIPA567047

Description

Immunogen sequence: LVALDHRKESV VVAVRGTMSL QDVLTDLSAE SEVLDVECEV QDRLAHKGIS QAARYVYQRL INDGILSQAF SIA Highest antigen sequence identity to the following orthologs - mouse 78%, rat 80%.

Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. [UniProt].

Specifications

• Antigen: DAGLB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAGLB
• Gene Alias: DAGLB; DAGLBETA; DGL-beta; diacylglycerol lipase beta; diacylglycerol lipase, beta; E330036I19Rik; KCCR13L; RGD1310193; sn1-specific diacylglycerol lipase beta
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 221955
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8NCG7
• Gene Symbols: DAGLB
• Immunogen: Recombinant Human DAGLB. Recombinant protein control fragment (Product #RP-105476).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov