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Invitrogen™ DAGLB Polyclonal Antibody
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Catalog No. PIPA567047
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100 μL
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PIPA567047 100 μL
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Catalog No. PIPA567047 Supplier Invitrogen™ Supplier No. PA567047
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LVALDHRKESV VVAVRGTMSL QDVLTDLSAE SEVLDVECEV QDRLAHKGIS QAARYVYQRL INDGILSQAF SIA Highest antigen sequence identity to the following orthologs - mouse 78%, rat 80%.

Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen DAGLB
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DAGLB
Gene Accession No. Q8NCG7
Gene Alias DAGLB; DAGLBETA; DGL-beta; diacylglycerol lipase beta; diacylglycerol lipase, beta; E330036I19Rik; KCCR13L; RGD1310193; sn1-specific diacylglycerol lipase beta
Gene Symbols DAGLB
Host Species Rabbit
Immunogen Recombinant Human DAGLB. Recombinant protein control fragment (Product #RP-105476).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221955
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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