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Invitrogen™ Dand5 Monoclonal Antibody (340531)
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Catalog No. PIMA524073
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100 μg
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PIMA524073 100 μg
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Catalog No. PIMA524073 Supplier Invitrogen™ Supplier No. MA524073
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Description

Rat Monoclonal Antibody

In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) COCO, rhDAN, recombinant mouse (rm) Gremlin, rmCerberus, and recombinant chicken Caronte is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dand5
Applications Western Blot
Classification Monoclonal
Clone 340531
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene DAND5
Gene Accession No. Q76LW6
Gene Alias CER2; CER2CRL2; cerberus 2; Cerberus like-2; cerberus-like 2; cerberus-like protein 2; Cerl2; Cerl-2; Cerr2; CKTSF1B3; CKTSF1B3MGC126849; coco; CRL2; Cysteine knot superfamily 1, BMP antagonist 3; DAN domain BMP antagonist family member 5; DAN domain family member 5; DAN domain family member 5, BMP antagonist; DAN domain family, member 5; Dand5; DANTE; Dte; FLJ38607; GREM3; GREM3cerberus 2; gremlin-3; MGC126849; SP1
Gene Symbols DAND5
Host Species Rat
Immunogen E. coli-derived recombinant mouse COCO Arg24-Leu185.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23863
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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