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DAP3 Mouse anti-Human, Clone: OTI1B12, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526568

Catalog No. PIMA526568



Description

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Recently, five novel apoptotic genes (named DAP genes for: Death Associated Proteins) have been identified that code for proteins, which display a diverse spectrum of biochemical activities. These include a novel type of calcium/calmodulin-regulated kinase which carries ankyrin repeats and a death domain (DAP-kinase), a nucleotide-binding protein (DAP-3), a small proline-rich cytoplasmic protein (DAP-1), and a novel homolog of the eIF4G translation initiation factor (DAP-5) (4). DAP-3 has an ATP/GTP binding motive (P-loop) and has been isolated from human and mouse, and named as hDAP-3 and mDAP-3 (Death Associated Protein-3), respectively (2-3). Sequence analysis revealed an 82% amino acid identity between human and mouse protein. In situ hybridization and northern blot analysis showed an abundant mRNA expression with a pronounced expression in highly proliferative epithelial compartments. Overexpression of DAP-3 leads to cytochrome c release and induction of cell death. DAP-3 mediated apoptosis was shown to depend on a functional P-loop. mDAP-3 is localized to the mitochondrial matrix and in contrast to cytochrome c, retained its mitochondrial localization during apoptosis induction (2).
Specifications

Specifications

DAP3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P51398
DAP-3, MRP-S29, MRPS29, bMRP-10, 28S ribosomal protein S29, mitochondrial, S29mt, death-associated protein 3, ionizing radiation resistance conferring protein, mitochondrial 28S ribosomal protein S29
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7818
Immunohistochemistry (Paraffin), Western Blot
OTI1B12
Unconjugated
DAP3
Liquid
DAP3
Human recombit protein fragment corresponding to amino acids 161-398 of DAP3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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