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Invitrogen™ DARC Recombinant Mouse Monoclonal Antibody (2C3)
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Catalog No. PIMA548104
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200 μg
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PIMA548104 200 μg
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Catalog No. PIMA548104 Supplier Invitrogen™ Supplier No. MA548104
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Description

Mouse Recombinant Monoclonal Antibody

Specificity: The antibody binds specifcally to the pentapeptide FEDVW of the Duffy receptor.

ACKR1 or DARC is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades resulting instead in chemokine sequestration, degradation, or transcytosis. ACKR1 is also known as an interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. It has a promiscuous chemokine-binding profile by interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. ACKR1 also acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and for the malaria parasites P.vivax and P.knowlesi.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DARC
Applications ELISA, Flow Cytometry, Inhibition Assays
Classification Recombinant Monoclonal
Clone 2C3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene ACKR1
Gene Accession No. Q16570
Gene Alias AA162249; ACKR1; Atypical chemokine receptor 1; atypical chemokine receptor 1 (Duffy blood group); CCBP1; CD234; CD234 antigen; CTA-134P22.3; DARC; Dfy; Duffy Antigen; Duffy antigen chemokine receptor; Duffy antigen receptor for chemokines; duffy antigen/chemokine receptor; Duffy blood group antigen; duffy blood group chemokine receptor; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; ESTM35; FY; Fy Antigen; Fy glycoprotein; FYDuffy blood group; glycoprotein D; GPD; GPDWBCQ1; GpFy; HGNC:4035; OTTHUMP00000060081; Plasmodium vivax receptor; WBCQ1
Gene Symbols ACKR1
Host Species Mouse
Immunogen CHO cells transfected with cDNA encoding the Duffy glycoprotein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2532
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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