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Invitrogen™ DARPP-32 Polyclonal Antibody
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Catalog No. PA14650
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100 μL
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PA14650 100 μL
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Catalog No. PA14650 Supplier Invitrogen™ Supplier No. PA14650
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and Xenopus based on 100% sequence homology. This antibody is specific for the ~32 kDa DARPP-32 protein.

DARPP-32 is a dopamine (DA) and AMP-regugated ~32 kDa phosphoprotein that is associated with dopaminoceptive neurons. The protein inhibits Protein Phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regugation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac™.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DARPP-32
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene Ppp1r1b
Gene Accession No. Q60829, Q6J4I0
Gene Alias AU040756; DARPP32; DARPP-32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine and cAMP-regulated neuronal phosphoprotein 32; dopamine- and cAMP-regulated phosphoprotein DARPP-32; FLJ20940; IPPD; neuronal phosphoprotein DARPP-32; OTTHUMP00000164275; OTTHUMP00000164276; Ppp1r1b; PPR1B; protein pho; protein phosphatase 1 regulatory inhibitor subunit 1B; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B
Gene Symbols Ppp1r1b
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the N-terminal region of rat PPP1R1B conjugated to KLH.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19049, 360616
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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