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Tocris Bioscience™ Dasatinib
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Catalog No. 6793100
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100 mg
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Catalog No. Quantity
67-931-00 100 mg
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Description

Highly potent pan-Src/Bcr-Abl inhibitor

Dasatinib is a highly potent pan-Src/Bcr-Abl inhibitor (Ki values are 16 and 30 pM, respectively. Inhibits Bcr-Abl, Src, Lck, Fyn, c-kit and Yes with IC50 values in the subnanomolar range. Inhibits proliferation of tumor cells in vitro and exhibits anticancer acivity in vivo in a mouse chronic myelogenous leukemia (CML) xenograft model. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC50 values are 2.1and 5.5 μM, respectively). Dasatinib also enhances CD3-targeted lentiviral vector-mediated gene transfer by 3 to 10-fold.

Specifications

Chemical Name or Material N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
CAS 302962-49-8
Synonym BMS-354825
Quantity 100 mg
Molecular Formula C22H26ClN7O2S
Formula Weight 488.01
Purity 98%
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