Invitrogen™ DATF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101330

Catalog No. PIPA5101330

Description

Antibody detects endogenous levels of total DIDO1.

Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.

Specifications

• Antigen: DATF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DIDO1
• Gene Alias: 6720461J16Rik; BYE1; C20orf158; D130048F08Rik; DATF1; DATF-1; death associated transcription factor 1; death inducer-obliterator 1; death inducer-obliterator-2; death inducer-obliterator-3; death-associated transcription factor 1; Death-inducer obliterator 1; dido; Dido1; DIDO2; DIDO3; DIO1; DIO-1; dJ885L7.8; KIAA0333
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11083, 23856
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8C9B9, Q9BTC0
• Gene Symbols: DIDO1
• Immunogen: A synthesized peptide derived from human DIDO1(Accession Q9BTC0), corresponding to amino acid residues P2006-G2056.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov