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Invitrogen™ DATF1 Polyclonal Antibody
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Catalog No. PIPA536337
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100 μL
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PIPA536337 100 μL
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Catalog No. PIPA536337 Supplier Invitrogen™ Supplier No. PA536337
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 244 kDa. Purity is >95% by SDS-PAGE.

Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DATF1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene DIDO1
Gene Accession No. Q8C9B9, Q9BTC0
Gene Alias 6720461J16Rik; BYE1; C20orf158; D130048F08Rik; DATF1; DATF-1; death associated transcription factor 1; death inducer-obliterator 1; death inducer-obliterator-2; death inducer-obliterator-3; death-associated transcription factor 1; Death-inducer obliterator 1; dido; Dido1; DIDO2; DIDO3; DIO1; DIO-1; dJ885L7.8; KIAA0333
Gene Symbols DIDO1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 154-198 of human Dio-1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11083, 23856, 362286
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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