Invitrogen™ DATF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536337

Catalog No. PIPA536337

Description

This antibody detects endogenous protein at a molecular weight of 244 kDa. Purity is >95% by SDS-PAGE.

Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.

Specifications

• Antigen: DATF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DIDO1
• Gene Alias: 6720461J16Rik; BYE1; C20orf158; D130048F08Rik; DATF1; DATF-1; death associated transcription factor 1; death inducer-obliterator 1; death inducer-obliterator-2; death inducer-obliterator-3; death-associated transcription factor 1; Death-inducer obliterator 1; dido; Dido1; DIDO2; DIDO3; DIO1; DIO-1; dJ885L7.8; KIAA0333
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11083, 23856, 362286
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8C9B9, Q9BTC0
• Gene Symbols: DIDO1
• Immunogen: Synthetic peptide corresponding to amino acids 154-198 of human Dio-1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG