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Invitrogen™ DAZAP1 Polyclonal Antibody
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Catalog No. PIPA552074
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100 μL
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PIPA552074 100 μL
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Catalog No. PIPA552074 Supplier Invitrogen™ Supplier No. PA552074
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EPRDSKSQAP GQPGASQWGS RVVPNAANGW AGQPPPTWQQ GYGPQGMWVP AGQAIGGYGP PPAGRGAPPP PPPFTSYIVS TPPGGFPPPQ GFPQGYGAPP QFSFGYGPPP PPPDQFAPPG VPPPPA Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
TRUSTED_SUSTAINABILITY

Specifications

Antigen DAZAP1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DAZAP1
Gene Accession No. Q96EP5, Q9JII5
Gene Alias 2410042M16Rik; DAZ associated protein 1; DAZAP1; DAZ-associated protein 1; Deleted in azoospermia-associated protein 1; LOC561459 protein; LOW QUALITY PROTEIN: DAZ-associated protein 1; MGC19907; mPrrp; testicular tissue protein Li 50
Gene Symbols DAZAP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DAZAP1. Recombinant protein control fragment (Product #RP-102468).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26528, 362836, 70248
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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