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Tocris Bioscience™ dBET6
GREENER_CHOICE

Catalog No. 69455
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective (+)-JQ1 based Degrader (PROTAC™) targeting BET bromodomains, active in vivo

dBET6 is a potent and selective Degrader (PROTAC™) of BET bromodomains (IC50 = ∽10 nM). dBET6 comprises BET antagonist (+)-JQ1 (Cat.No. 4499) conjugated to a cereblon E3 ubiquitin ligase ligand. Exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines through BRD4 degradation. Induces apoptosis. Reduces leukemic burden in a mouse model of T-ALL. Cell permeable. PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material (6 S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6 H-thieno[3,2-f][1,2,4 ]triazolo[4,3-a][1,4 ]diazepine-6-acetamide
CAS 1950634-92-0
Quantity 5 mg
Target Active Degraders
Molecular Formula C42H45ClN8O7S
Purity 0.98
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