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Tocris™ dBRD9

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Quantity:
5 mg
Description
Potent and selective Degrader (PROTAC™) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Specifications
Specifications
Chemical Name or Material | 2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride |
CAS | 2341840-98-8 |
Quantity | 5 mg |
Molecular Formula | C40H45N7O10.2HCl |
Formula Weight | 856.75 |
Product Type | Degrader |
Purity | 98% |
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