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Tocris Bioscience™ dBRD9
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Catalog No. 66065
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66-065 5 mg
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Catalog No. 66-065 Supplier Tocris Bioscience™ Supplier No. 6606/5
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Description

Potent and selective BRD9 Degrader (PROTAC™)

Potent and selective Degrader (PROTAC™) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride
CAS 2341840-98-8
Quantity 5 mg
Molecular Formula C40H45N7O10.2HCl
Formula Weight 856.75
Product Type Degrader
Purity 98%
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