Invitrogen™ DCC Monoclonal Antibody (531505)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524233

Catalog No. PIMA524233

Description

DCC Monoclonal Antibody for IHC (P)

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Specifications

• Antigen: DCC
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: DCC
• Gene Alias: C030036D22Rik; Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; Dcc; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; tumor suppressor protein DCC
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 1630
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin)
• Clone: 531505
• Formulation: PBS with No Preservative
• Gene Accession No.: P43146
• Gene Symbols: DCC
• Immunogen: E. coli-derived recombinant human DCC Ser1323-Phe1447.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b