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Invitrogen™ DCC Monoclonal Antibody (531505)

Catalog No. PIMA524233
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100 μg
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Catalog No. Quantity
PIMA524233 100 μg
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Catalog No. PIMA524233 Supplier Invitrogen™ Supplier No. MA524233
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Description

Mouse Monoclonal Antibody

Reconstitute at 0.2 mg/mL in sterile PBS.

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCC
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 531505
Conjugate Unconjugated
Formulation PBS with No Preservative
Gene DCC
Gene Accession No. P43146
Gene Alias C030036D22Rik; Colorectal cancer suppressor; colorectal tumor suppressor; CRC18; CRCR1; Dcc; DCC netrin 1 receptor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; MRMV1; Netrin receptor DCC; NTN1R1; putative colorectal tumor suppressor; tumor suppressor protein DCC
Gene Symbols DCC
Host Species Mouse
Immunogen E. coli-derived recombinant human DCC Ser1323-Phe1447.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1630
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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