DCC Mouse anti-Human, Clone: OTI5D10, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA804517

Catalog No. 50-168-0281

Description

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Specifications

• Antigen: DCC
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P43146
• Gene Symbols: DCC
• Immunogen: Full length human recombit protein of human DCC produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI5D10
• Conjugate: Unconjugated
• Gene: DCC
• Gene Alias: CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1630
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid