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Tocris Bioscience™ DCLK1-IN-1
GREENER_CHOICE

Catalog No. 72855
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor; orally bioavailable

DCLK1-IN-1 is a potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor (IC50 values are DCLK1 =9.5 and 57.2 nM and DCLK2 = 31 and 103 nM in binding and kinase assay, respectively). Exhibits no significant activity against ERK5, ACK, BRD4 and LRRK2. Exhibits DCLK inhibition in pancreatic ductal adenocarcinoma (PDAC) organoid models. Orally bioavailable.

Specifications

Chemical Name or Material 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5-(2,2,2-trifluoroethyl)-6 H-pyrimido[4,5-b][1,4 ]benzodiazepin-6-one
CAS 2222635-15-4
Quantity 5 mg
Target Other Kinase Inhibitors
Molecular Formula C26H28F3N7O2
Purity 0.98
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