Invitrogen™ DCLK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583509

Catalog No. PIPA583509

Description

Immunogen sequence: SKALKGDHRC GETETPKSCS EVAGCKAAMR HQGKIPEELS LDDRARTQKK WGRGKWEPEP SSKPPREATL EERHARGEKH LGVEIEKTSG EIIRCEKCKR ERELQQSLER ERLSLGTSEL DMGKGPMYDV EKLVRTRSCR RSPEANPASG.

DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.

Specifications

• Antigen: DCLK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCLK3
• Gene Alias: BC056929; C730036H08; CLICK-I and II-related; Click-I, -II related; CLICK-I,II-related; CLR; Dcamkl3; DCDC3C; DCK3; Dclk3; doublecortin and CaM kinase-like 3; doublecortin domain-containing protein 3C; doublecortin like kinase 3; doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3; hCG_16695; KIAA1765; RGD1309232; serine/threonine-protein kinase DCLK3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 85443
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9C098
• Gene Symbols: DCLK3
• Immunogen: Recombinant protein corresponding to Human DCLK3. Recombinant protein control fragment (Product #RP-108351).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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