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Invitrogen™ DCLK3 Polyclonal Antibody
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Catalog No. PIPA599227
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100 μL
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PIPA599227 100 μL
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Catalog No. PIPA599227 Supplier Invitrogen™ Supplier No. PA599227
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DCLK3.

DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCLK3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DCLK3
Gene Accession No. Q9C098
Gene Alias BC056929; C730036H08; CLICK-I and II-related; Click-I, -II related; CLICK-I,II-related; CLR; Dcamkl3; DCDC3C; DCK3; Dclk3; doublecortin and CaM kinase-like 3; doublecortin domain-containing protein 3C; doublecortin like kinase 3; doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3; hCG_16695; KIAA1765; RGD1309232; serine/threonine-protein kinase DCLK3
Gene Symbols DCLK3
Host Species Rabbit
Immunogen A synthesized peptide derived from human DCLK3(Accession Q9C098), corresponding to amino acid residues T312-I362.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 85443
Target Species Human, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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