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Invitrogen™ DCLK3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA599227
Description
Antibody detects endogenous levels of total DCLK3.
DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
Specifications
DCLK3 | |
Polyclonal | |
Unconjugated | |
DCLK3 | |
BC056929; C730036H08; CLICK-I and II-related; Click-I, -II related; CLICK-I,II-related; CLR; Dcamkl3; DCDC3C; DCK3; Dclk3; doublecortin and CaM kinase-like 3; doublecortin domain-containing protein 3C; doublecortin like kinase 3; doublecortin-like and CAM kinase-like 3; Doublecortin-like kinase 3; hCG_16695; KIAA1765; RGD1309232; serine/threonine-protein kinase DCLK3 | |
Rabbit | |
Affinity chromatography | |
RUO | |
85443 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q9C098 | |
DCLK3 | |
A synthesized peptide derived from human DCLK3(Accession Q9C098), corresponding to amino acid residues T312-I362. | |
100 μL | |
Primary | |
Human, Monkey | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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