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Invitrogen™ DCP1A Polyclonal Antibody
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Catalog No. PIPA540931
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100 μL
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PIPA540931 100 μL
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Catalog No. PIPA540931 Supplier Invitrogen™ Supplier No. PA540931
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Description

Rabbit Polyclonal Antibody

Peptide sequence: EEMPSGSQDK SAPSGHKHLT VEELFGTSLP KEQPAVVGLD SEEMERLPGD Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCP1A
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Dcp1a
Gene Accession No. Q9NPI6
Gene Alias 1110066A22Rik; 4930568L04Rik; AU019772; D14Ertd817e; DCP1 decapping enzyme homolog A; DCP1 decapping enzyme homolog A (S. cerevisiae); DCP1 decapping enzyme-like protein A; DCP1A; decapping enzyme; decapping enzyme hDcp1a; decapping mRNA 1A; FLJ21691; HSA275986; MAD homolog 4 interacting transcription coactivator 1; MAD homolog 4-interacting transcription coactivator 1; Mitc1; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; RGD1561298; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; test2; transcription factor SMIF
Gene Symbols Dcp1a
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human DCP1A (aa 199-248).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55802
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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