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Invitrogen™ DCP1A Polyclonal Antibody
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Catalog No. PIPA582478
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100 μL
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PIPA582478 100 μL
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Catalog No. PIPA582478 Supplier Invitrogen™ Supplier No. PA582478
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RSPLLNQPVP ELSHASLIAN QSPFRAPLNV TNTAGTSLPS VDLLQKLRLT PQHDQIQTQP LGKGAMVASF SPAAGQLATP ESFIEPPSKT AAARVAASAS LSNMVLAPLQ SMQQNQDPEV FVQPKVLSSA SA Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 82%.

Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCP1A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Dcp1a
Gene Accession No. Q9NPI6
Gene Alias 1110066A22Rik; 4930568L04Rik; AU019772; D14Ertd817e; DCP1 decapping enzyme homolog A; DCP1 decapping enzyme homolog A (S. cerevisiae); DCP1 decapping enzyme-like protein A; DCP1A; decapping enzyme; decapping enzyme hDcp1a; decapping mRNA 1A; FLJ21691; HSA275986; MAD homolog 4 interacting transcription coactivator 1; MAD homolog 4-interacting transcription coactivator 1; Mitc1; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; RGD1561298; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; test2; transcription factor SMIF
Gene Symbols Dcp1a
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DCP1A. Recombinant protein control fragment (Product #RP-108146).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55802
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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