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Invitrogen™ DCP1A Recombinant Rabbit Monoclonal Antibody (K01_4N61)
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Catalog No. MA567472
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MA567472 100 μL
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Catalog No. MA567472 Supplier Invitrogen™ Supplier No. MA567472
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Description

Rabbit Recombinant Monoclonal Antibody

DCP1A Recombinant Monoclonal Antibody for Western Blot

Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCP1A
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_4N61
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 150mM NaCl, 0.05% BSA and 0.02% sodium azide; pH 7.4
Gene Dcp1a
Gene Accession No. Q91YD3, Q9NPI6
Gene Alias 1110066A22Rik; 4930568L04Rik; AU019772; D14Ertd817e; DCP1 decapping enzyme homolog A; DCP1 decapping enzyme homolog A (S. cerevisiae); DCP1 decapping enzyme-like protein A; DCP1A; decapping enzyme; decapping enzyme hDcp1a; decapping mRNA 1A; FLJ21691; HSA275986; MAD homolog 4 interacting transcription coactivator 1; MAD homolog 4-interacting transcription coactivator 1; Mitc1; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; RGD1561298; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; test2; transcription factor SMIF
Gene Symbols Dcp1a
Host Species Rabbit
Immunogen A synthesized peptide derived from human DCP1A
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361109, 55802, 75901
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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