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DCPIB, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Volume-regulated anion channel (VRAC) blocker (IC50 ∽ 2 μM in rat pancreatic β-cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 μM, in vitro.
Specifications
Quantity | 10 mg |
Formula Weight | 427.37 |
Percent Purity | >98% |
Chemical Name or Material | DCPIB |
Safety and Handling
Recommended Storage | Store at +4°C |
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