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DCPIB, Tocris Bioscience™
GSA_VAGREENER_CHOICE

Catalog No. 154010
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Catalog No. Quantity
15-401-0 10 mg
15-405-0 50 mg
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Catalog No. 15-401-0 Supplier R&D Systems Supplier No. 1540/10
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Description

Blocker of VRAC/ICl, swell

Volume-regulated anion channel (VRAC) blocker (IC50 ∽ 2 μM in rat pancreatic β-cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 μM, in vitro.

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Chemical Identifiers

CAS 82749-70-0
Molecular Formula C22H28Cl2O4
Molecular Weight (g/mol) 427.362
InChI Key KHKGTPJPBOQECW-UHFFFAOYSA-N
Synonym SN-401, 4-2-butyl-6,7-dichlor-2-cyclopentyl-indan-1-on-5-yl oxybutyric acid, d0j3qc, 4-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3h-inden-5-yl oxy butanoic acid, 4-2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl oxybutyric acid, 4-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1h-inden-5-yl oxy butanoic acid, 4-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1h-inden-5-yl oxy butanoic acid, + 4-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1h-inden-5-yl oxy butanoic acid, -4-2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1h-inden-5-yl oxy butanoic acid
PubChem CID 10071166
IUPAC Name 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid
SMILES CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCCCC(=O)O)C3CCCC3

Specifications

Quantity 10 mg
Formula Weight 427.37
Percent Purity >98%
Chemical Name or Material DCPIB

Safety and Handling

Recommended Storage Store at +4°C
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