Invitrogen™ DcR3 Polyclonal Antibody

Catalog No.	Quantity
PIPA589348	100 μL

Catalog No. PIPA589348 Supplier Invitrogen™ Supplier No. PA589348

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TYPWRDAETG ERLVCAQCPP GTFVQRPCRR DSPTTCGPCP PRHYTQFWNY LERCRYCNVL CGEREEEARA CHATHNRACR CRTGFFAHAG FCLEHASCPP GAGVIAPGTP SQNTQCQPCP PGTFSASSSS SEQCQPHRNC TALGLALNVP GSSSHDTLCT SCTGFPLSTR VPGAEECERA VIDFVAFQDI SIKRLQRLLQ ALEAPEGWGP TPRAGRAALQ LKLRRRLTEL LGAQDGALLV RLLQALRVAR MPGLERSVRE RFLPVH; Positive Samples: HT-1080, Mouse lung.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

Specifications

• Antigen: DcR3
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.91 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: TNFRSF6B
• Gene Accession No.: O95407
• Gene Alias: DcR3; Decoy receptor 3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; decoy receptor for Fas ligand; DJ583P15.1.1; hCG_2044836; M68; M68E; OTTHUMP00000031583; TNF receptor superfamily member 6b; TNFRSF6B; TR6; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily member 6b, decoy; tumor necrosis factor receptor superfamily, member 6b, decoy; UNQ186/PRO212
• Gene Symbols: TNFRSF6B
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-300 of human TNFRSF6B (NP_0038141).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8771
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG