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Invitrogen™ DcR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523645

Catalog No. PIPA523645


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Description

Description

DcR3 Polyclonal Antibody for Western Blot, IHC (P), Flow

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF (tumor necrosis factor) and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 (tumor necrosis factor receptor 1) and Fas. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE (interleukin-1-beta converting enzyme)/CED-3 (C. elegans death receptor-3) protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx (death associated protein 6). Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DcR3
Polyclonal
Unconjugated
TNFRSF6B
DcR3; Decoy receptor 3; decoy receptor 3 variant 1; decoy receptor 3 variant 2; decoy receptor for Fas ligand; DJ583P15.1.1; hCG_2044836; M68; M68E; OTTHUMP00000031583; TNF receptor superfamily member 6b; TNFRSF6B; TR6; tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily member 6b, decoy; tumor necrosis factor receptor superfamily, member 6b, decoy; UNQ186/PRO212
Rabbit
Antigen affinity chromatography, Protein A
RUO
8771
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.4
O95407
TNFRSF6B
KLH conjugated synthetic peptide between 22-48 amino acids from the N-terminal region of human TNFRSF6B.
400 μL
Primary
Human
Antibody
IgG
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