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Invitrogen™ DCT Polyclonal Antibody
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Catalog No. PIPA590899
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100 μL
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PIPA590899 100 μL
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Catalog No. PIPA590899 Supplier Invitrogen™ Supplier No. PA590899
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NVCGSQQGRG QCTEVRADTR PWSGPYILRN QDDRELWPRK FFHRTCKCTG NFAGYNCGDC KFGWTGPNCE RKKPPVIRQN IHSLSPQERE QFLGALDLAK KRVHPDYVIT TQHWLGLLGP NGTQPQFANC SVYDFFVWLH YYSVRDTLLG PGRPYRAIDF SHQGPAFVTW HRYHLLCLER DLQRLIGNES FALPYWNFAT GRNECDVCTD QLFGAARPDD PTLISRNSRF SSWETVCDSL DDYNHLVTLC NGTYEGLLRR NQMGRNSMKL PTLKDIRDCL SLQKFDNPPF FQNSTFSFRN A; Positive Samples: MCF7, A-375, HeLa, Mouse brain; Cellular Location: Melanosome membrane, Single-pass type I membrane protein.

The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCT
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 3.66 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene DCT
Gene Accession No. P29812, P40126
Gene Alias Dct; DOPAchrome conversion factor; dopachrome delta isomerase; dopachrome delta-isomerase; DOPAchrome isomerase; DOPAchrome oxidoreductase; dopachrome tautomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; hypothetical protein LOC664745; L-dopachrome Delta-isomerase; L-dopachrome isomerase; L-dopachrome tautomerase; melanogenic enzyme; tyrosinase-related protein 2; trp2; RGD1564975; slaty; SLATY locus protein; slt; trp2; TRP-2; tyrosinase related protein 2; tyrosinase related protein-2; tyrosinase-related protein 2; tyrosinase-related protein-2; tyrosine-related protein 2; Tyrp2; Tyrp-2; zgc:109860
Gene Symbols DCT
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 50-350 of human DCT (NP_0019132).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13190, 1638
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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