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Invitrogen™ DCUN1D1 Polyclonal Antibody
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Catalog No. PIPA530745
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100 μL
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PIPA530745 100 μL
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Catalog No. PIPA530745 Supplier Invitrogen™ Supplier No. PA530745
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (88%), Xenopus laevis (97%), Chicken (98%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCUN1D1
Applications Western Blot
Classification Polyclonal
Concentration 0.24 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene DCUN1D1
Gene Accession No. Q96GG9
Gene Alias DCN1; DCN1, defective in cullin neddylation 1, domain containing 1; DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Dcun1d1; DCUN1L1; defective in cullin neddylation 1 domain containing 1; defective in cullin neddylation protein 1-like protein 1; pTes3; Rp42; RP42 homolog; SCCRO; SCRO; squamous cell carcinoma related oncogene; squamous cell carcinoma-related oncogene; Tes3; testis derived transcript 3; testis-specific protein 3
Gene Symbols DCUN1D1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human DCUN1D1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54165
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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