Invitrogen™ DCUN1D1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583298

Catalog No. PIPA583298

Description

Immunogen sequence: RQFMIFTQSS EKTAVSCLSQ NDWKLDVATD NFFQNPELYI RESVKGSLDR KKLEQLYNR.

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [UniProt].

Specifications

• Antigen: DCUN1D1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DCUN1D1
• Gene Alias: DCN1; DCN1, defective in cullin neddylation 1, domain containing 1; DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Dcun1d1; DCUN1L1; defective in cullin neddylation 1 domain containing 1; defective in cullin neddylation protein 1-like protein 1; pTes3; Rp42; RP42 homolog; SCCRO; SCRO; squamous cell carcinoma related oncogene; squamous cell carcinoma-related oncogene; Tes3; testis derived transcript 3; testis-specific protein 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54165
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96GG9
• Gene Symbols: DCUN1D1
• Immunogen: Recombinant protein corresponding to Human DCUN1D1. Recombinant protein control fragment (Product #RP-96262).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov