Invitrogen™ DDB2 Recombinant Rabbit Monoclonal Antibody (4Y2G5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535141

Catalog No. PIMA535141

Description

Immunogen sequence: DNVGNVILLN MDGKELWNLR MHKKKVTHVA LNPCCDWFLA TASVDQTVKI WDLRQVRGKA SFLYSLPHRH PVNAACFSPD GARLLTTDQK SEIRVYSASQ WDCPLGLIPH PHRHFQHLTP IKAAWHPRYN LIVVGRYPDP NFKSCTPYEL RTIDVFDGNS GKMMCQLYDP ESSGISSLNE FNPMGDTLAS AMGYHILIWS QEEARTRK.

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.

Specifications

• Antigen: DDB2
• Classification: Recombinant Monoclonal
• Concentration: 0.4 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q92466, Q99J79
• Gene Symbols: DDB2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-427 of human DDB2 (Q92466).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 4Y2G5
• Conjugate: Unconjugated
• Gene: DDB2
• Gene Alias: 2610043A19Rik; damage specific DNA binding protein 2; damage-specific DNA binding protein 2, 48kDa; damage-specific DNA-binding protein 2; DDB p48 subunit; DDB2; DDBb; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 107986, 1643
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid