Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA535141

Invitrogen™ DDB2 Recombinant Rabbit Monoclonal Antibody (4Y2G5)
GREENER_CHOICE

Catalog No. PIMA535141
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIMA535141 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIMA535141 Supplier Invitrogen™ Supplier No. MA535141
Add to Cart
Add to Cart

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: DNVGNVILLN MDGKELWNLR MHKKKVTHVA LNPCCDWFLA TASVDQTVKI WDLRQVRGKA SFLYSLPHRH PVNAACFSPD GARLLTTDQK SEIRVYSASQ WDCPLGLIPH PHRHFQHLTP IKAAWHPRYN LIVVGRYPDP NFKSCTPYEL RTIDVFDGNS GKMMCQLYDP ESSGISSLNE FNPMGDTLAS AMGYHILIWS QEEARTRK.

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DDB2
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 4Y2G5
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene DDB2
Gene Accession No. Q92466, Q99J79
Gene Alias 2610043A19Rik; damage specific DNA binding protein 2; damage-specific DNA binding protein 2, 48kDa; damage-specific DNA-binding protein 2; DDB p48 subunit; DDB2; DDBb; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE
Gene Symbols DDB2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 220-427 of human DDB2 (Q92466).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107986, 1643
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.