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DDB2 Mouse anti-Human, Clone: OTI2E12, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF810712

Encompass_Preferred

Catalog No. 50-167-0269


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.
Specifications

Specifications

DDB2
Monoclonal
Unconjugated
DDB2
DDBB, UV-DDB2, XPE
Mouse
Affinity Chromatography
RUO
1643
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI2E12
PBS with 8% trehalose and no preservative; pH 7.3
Q92466
DDB2
Human recombit protein fragment corresponding to amino acids 1-250 of human DDB2 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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