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Invitrogen™ DDB2 Polyclonal Antibody
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Catalog No. PIPA5114728
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100 μL
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PIPA5114728 100 μL
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Catalog No. PIPA5114728 Supplier Invitrogen™ Supplier No. PA5114728
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total DDB2.

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DDB2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene DDB2
Gene Accession No. Q92466, Q99J79
Gene Alias 2610043A19Rik; damage specific DNA binding protein 2; damage-specific DNA binding protein 2, 48kDa; damage-specific DNA-binding protein 2; DDB p48 subunit; DDB2; DDBb; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE
Gene Symbols DDB2
Host Species Rabbit
Immunogen A synthesized peptide derived from human DDB2(Accession Q92466), corresponding to amino acid residues T338-D388.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107986, 1643
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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