DDR1 Mouse anti-Human, Clone: 2G4E12, Abnova™

Catalog No.	Quantity
89-934-039	50 μL

Catalog No. 89-934-039 Supplier Abnova Corporation Supplier No. MAB12603

Description

Mouse monoclonal antibody raised against human DDR1.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

Specifications

• Antigen: DDR1
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: 2G4E12
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against human DDR1.
• Dilution: ELISA (1:10000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:300) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In ascites (0.03% sodium azide).
• Gene Alias: CAK/CD167/DDR/EDDR1/MCK10/NEP/NTRK4/PTK3/PTK3A/RTK6/TRKE
• Gene Symbols: DDR1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 602-681 of human DDR1.
• Quantity: 50 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 780
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1