Invitrogen™ DDR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579144

Catalog No. PIPA579144

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human U87 whole cell, rat C6 whole cell, mouse NIH/3T3 whole cell.

DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Specifications

• Antigen: DDR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ddr2
• Gene Alias: AW495251; CD_antigen: CD167b; CD167 antigen-like family member B; CD167b; CD167b antigen; cell migration-inducing protein 20; Ddr2; Discoidin domain receptor 2; discoidin domain receptor family, member 2; discoidin domain receptor tyrosine kinase 2; discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein; hydroxyaryl-protein kinase; MIG20a; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; Ntrkr3; receptor protein-tyrosine kinase TKT; RP11-572K18.1; TKT; TYRO10; tyrosine-protein kinase TYRO 10; tyrosine-protein kinase TYRO10; tyrosylprotein kinase
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18214, 4921, 685781
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: Q16832, Q62371
• Gene Symbols: Ddr2
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human DDR2 (834-855aa RDTKNRPSFQEIHLLLLQQGDE).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG