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MilliporeSigma™ DDX41, Mouse, Unlabeled, Clone: 4D8.2,

Catalog No. MABF1107MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF1107MI 100 μg Unconjugated
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Catalog No. MABF1107MI Supplier MilliporeSigma™ Supplier No. MABF1107

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Description

Mouse Monoclonal Antibody

Probable ATP-dependent RNA helicase DDX41 (UniProt: Q9UJV9; also known as DEAD box protein 41; DEAD box protein abstrakt homolog) is encoded by DDX41 (also known as ABS) gene (Gene ID 51428) in human. DDX41 belongs to the family of DEAD box helicase family of proteins, characterized by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif. DDX41 is reported to sense DNA virus in myeloid dendritic cells (mDCs) mediated by the adaptor STING (stimulator of interferon genes). DDX41 is reported to bind to both DNA and STING through a DEADc domain and then DDX41-STING complex localizes to the cytoplasm. DDX41 binds bacterial DNA in the infected cells and is shown to be more important than gamma-interferon-inducible protein IFI16 in the initial sensing of cytosolic B-form DNA in triggering the early burst of type I interferon response. Knockdown of DDX41 expression blocks the ability of mDCs to mount type I interferon and cytokine responses to DNA and DNA viruses. Ref.: Zhang, Z., et al. (2011). Nat. Immunol. 12(10): 959-966.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DDX41
Applications Western Blot
Classification Monoclonal
Clone 4D8.2
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse monoclonal antibody IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene DDX41, ABS
Gene Accession No. Q9UJV9
Host Species Mouse
Immunogen GST-tagged recombinant fragment corresponding to 115 amino acids from the N-terminal region of human DDX41.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_057306
Test Specificity Clone 4D8.2 detects DDX41 protein in HEPG2 cells by Western blotting and in human ovarian and cervical cancer tissue by immunohisotchemistry.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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