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Dectin-1/CLEC7A Mouse anti-Human, Janelia Fluor 646, Clone: BD6, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP121513JF646

Catalog No. NBP12513646


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Description

Description

Dectin-1/CLEC7A Monoclonal antibody specifically detects Dectin-1/CLEC7A in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

Dectin-1/CLEC7A
BD6
Flow Cytometry
Purified
CLEC7A
NIH3T3 cells expressing full length Beta-glucan receptor
Protein G purified
Signal Transduction
Primary
64581
Human
Flow Cytometry
Janelia Fluor 646
50mM Sodium Borate with 0.05% Sodium Azide
Beta-glucan receptor, BGR, CLECSF12DC-associated C-type lectin 1, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12, C-type lectin domain family 7 member A, C-type lectin domain family 7, member A, C-type lectin superfamily member 12, dectin-1, DECTIN1CANDF4, Dendritic cell-associated C-type lectin 1, dendritic cell-associated C-type lectin-1, hDectin-1, lectin-like receptor 1
Mouse
IgG2b
0.1mL
Store at 4°C in the dark.
Monoclonal
NBP1-21513 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Clone BD6 recognizes betaGR-A only.
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