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Invitrogen™ Dectin 1 Monoclonal Antibody (GE2)
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Catalog No. PIMA516692
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500 μg
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PIMA516692 500 μg
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Catalog No. PIMA516692 Supplier Invitrogen™ Supplier No. MA516692
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Description

Mouse Monoclonal Antibody

This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01EU/ug. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Mouse anti Human Dectin-1 antibody, clone GE2 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member.

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dectin 1
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
Clone GE2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Clec7a
Gene Accession No. Q9BXN2
Gene Alias Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082
Gene Symbols Clec7a
Host Species Mouse
Immunogen NIH3T3 cells expressing full length Beta-glucan receptor.
Purification Method Protein A
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64581
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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