Invitrogen™ Dectin-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597284

Catalog No. PIPA597284

Description

Immunogen sequence: SWDGSKRQCW QLGSNLLKID SSNELGFIVK QVSSQPDNSF WIGLSRPQTE VPWLWEDGST FSSNLFQIRT TATQENPSPN CVWIHVSVIY DQLCSVPSYS I Positive Samples: H-460, SGC-7901, HL-60, Mouse spleen, Mouse thymus, Mouse liver, Mouse lung, Rat spleen; Cellular Location: Cell membrane, Cytoplasm, Single-pass type II membrane protein.

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

Specifications

• Antigen: Dectin-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Clec7a
• Gene Alias: Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 502902, 56644, 64581
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.61 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6QLQ4, Q9BXN2
• Gene Symbols: Clec7a
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 140-240 of human CLEC7A (NP_922938.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov