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Invitrogen™ Dectin 2 Monoclonal Antibody (3D1)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA516250
Description
Dectin 2 Monoclonal Antibody for Western Blot, IHC (P), Flow
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcRg for internalization and to activate NF-kappaB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.
Specifications
Dectin 2 | |
Monoclonal | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q6EIG7 | |
CLEC6A | |
A blend of two peptides made to amino acids 44-63 and 90-106 of human Dectin-2. | |
100 μg | |
Primary | |
Human, Monkey | |
Antibody | |
IgG3 κ |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
3D1 | |
Unconjugated | |
CLEC6A | |
Clec4n; CLEC6A; Clec6a-ps1; CLECSF10; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin domain family 4, member n; C-type lectin domain family 6 member A; C-type lectin domain family 6, member A; C-type lectin domain family 6, member A, pseudogene 1; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; DECTIN2; dectin-2; Dectin-2p; Dendritic cell-associated C-type lectin 2; natural killer complex lectin; Nkcl | |
Mouse | |
Protein G | |
RUO | |
93978 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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