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Invitrogen™ Dectin 2 Monoclonal Antibody (3D1)
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Catalog No. PIMA516250
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100 μg
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Catalog No. Quantity
PIMA516250 100 μg
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Catalog No. PIMA516250 Supplier Invitrogen™ Supplier No. MA516250
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Description

Mouse Monoclonal Antibody

Sequence homology: Bovine/Sheep (83%), Mouse (65%), Rat (52%).

Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcRg for internalization and to activate NF-kappaB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dectin 2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 3D1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CLEC6A
Gene Accession No. Q6EIG7
Gene Alias Clec4n; CLEC6A; Clec6a-ps1; CLECSF10; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10; C-type lectin domain family 4, member n; C-type lectin domain family 6 member A; C-type lectin domain family 6, member A; C-type lectin domain family 6, member A, pseudogene 1; C-type lectin superfamily member 10; DC-associated C-type lectin 2; dectin 2; DECTIN2; dectin-2; Dectin-2p; Dendritic cell-associated C-type lectin 2; natural killer complex lectin; Nkcl
Gene Symbols CLEC6A
Host Species Mouse
Immunogen A blend of two peptides made to amino acids 44-63 and 90-106 of human Dectin-2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 93978
Target Species Human, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG3 κ
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Safety and Handling

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