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Invitrogen™ DEDD2 Polyclonal Antibody
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Catalog No. PIPA520214
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100 μg
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Catalog No. Quantity
PIPA520214 100 μg
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Catalog No. PIPA520214 Supplier Invitrogen™ Supplier No. PA520214
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Description

Rabbit Polyclonal Antibody

A suggested positive control is RAW264.7 cell lysate. PA5-20214 can be used with blocking peptide PEP-0311.

Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DEDD2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Dedd2
Gene Accession No. Q8QZV0, Q8WXF8
Gene Alias 2410050E11Rik; death effector domain containing 2; death effector domain-containing DNA binding protein 2; death effector domain-containing DNA-binding protein 2; death effector domain-containingDNA binding protein 2; DED-containing protein FLAME-3; DEDD2; DNA-binding death effector domain-containing protein 2; FADD-like anti-apoptotic molecule 3; FLAME3; FLAME-3; PSEC0004
Gene Symbols Dedd2
Host Species Rabbit
Immunogen A peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 162989, 67379, 687118
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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