Invitrogen™ DEFA4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103124

Catalog No. PIPA5103124

Description

Antibody detects endogenous levels of total Defensin alpha 4.

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.

Specifications

• Antigen: DEFA4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DEFA4
• Gene Alias: Alpha-defensin 4; corticostatin; Crp4; DEF4; Defa28; Defa4; Defcr4; defensin alpha 4; Defensin, alpha 4; defensin, alpha 4, corticostatin; defensin, alpha 4, preproprotein; defensin, alpha, 4; Defensin-related cryptdin-4; HNP-4; HP4; HP-4; Neutrophil defensin 4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13238, 1669
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P12838, P28311
• Gene Symbols: DEFA4
• Immunogen: A synthesized peptide derived from human DEFA4(Accession P12838), corresponding to amino acid residues I3-A53.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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