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Invitrogen™ DEFB121 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA575996
Description
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Beta-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, beta-defensins are developmentally regulated. The family of beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many beta-defensins also are involved in sperm maturation and capacitation. beta-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, beta-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other beta-defensins, it does not appear to be regulated by androgens.
Specifications
DEFB121 | |
Polyclonal | |
Unconjugated | |
DEFB121 | |
Beta-defensin 121; beta-defensin 21; DB121; DEFB121; DEFB21; DEFB-21; defensin beta 121; defensin, beta 121; defensin, beta 21; ESC42RELC | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
245934 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
Q5J5C9 | |
DEFB121 | |
Recombinant full length Human DEFB121. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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