Invitrogen™ DEFA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103122

Catalog No. PIPA5103122

Description

Antibody detects endogenous levels of total Defensin alpha1.

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Specifications

• Antigen: DEFA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DEFA1
• Gene Alias: alpha-defensin 1; Cryptdin-1; DEF1; Defa1; DEFA1B; DEFA2; Defcr; Defcr1; defensin alpha 1; defensin related cryptdin peptide 1; defensin, alpha 1; defensin, alpha 1, myeloid-related sequence; defensin, alpha 2; defensin-1; defensin-related cryptdin peptide; HNP-1; HNP-2; HP 1-56; HP1; HP-1; HP-2; MRS; myeloid-related sequence; neutrophil defensin 1; Neutrophil defensin 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13216, 1667
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P11477, P59665
• Gene Symbols: DEFA1
• Immunogen: A synthesized peptide derived from human DEFA1; DEFA1B(Accession P59665), corresponding to amino acid residues I40-W90.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov