Invitrogen™ DELE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534403

Catalog No. PIPA534403

Description

A suggested positive control is rat brain tissue lysate. PA5-34403 can be used with blocking peptide PEP-1445.

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Specifications

• Antigen: DELE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dele1
• Gene Alias: 0610009O20Rik; 2700004E22Rik; DAP3-binding cell death enhancer 1; Death ligand signal enhancer; Dele; Dele1; KIAA0141; RIKEN cDNA 0610009O20 gene
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9812
• Content And Storage: 4°C, do not freeze
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q14154
• Gene Symbols: Dele1
• Immunogen: An 18 amino acid synthetic peptide near the amino terminus of human DELE.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov