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Invitrogen™ Dematin Polyclonal Antibody
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Catalog No. PIPA5140094
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100 μL
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PIPA5140094 100 μL
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Catalog No. PIPA5140094 Supplier Invitrogen™ Supplier No. PA5140094
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: DDDSGEEMKA LRERQREELS KVTSNLGKMI LKEEMEKSLP IRRKTRSLPD RTPFHTSLHQ GT Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 92%.

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Dematin
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DMTN
Gene Accession No. Q08495
Gene Alias AI325486; dematin; dematin actin binding protein; dematin actin-binding protein; DMT; Dmtn; Epb4.9; Epb49; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9
Gene Symbols DMTN
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DMTN. Recombinant protein control fragment (Product #RP-108960).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2039
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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