Dematin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-1190	Proteintech Group Inc 168081AP150UL	150 μL

Description

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3′ coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal domit Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: Dematin
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q08495, Q9WV69
• Gene ID (Entrez): 13829, 2039, 361069
• Immunogen: Dematin Fusion Protein Ag10300
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: DMTN

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Dematin, DMT, DMTN, EPB49
• Gene Symbols: Dmtn
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody