Dematin Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-4430	100 μL

Catalog No. 50-198-4430 Supplier Bioss Supplier No. BS20187R

Description

Rabbit Polyclonal Antibody

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3′ coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: Dematin
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: DMTN
• Gene Accession No.: Q08495
• Gene Alias: AI325486; Dematin; dematin actin binding protein; Dematin actin-binding protein; DMT; Dmtn; Epb4.9; EPB49; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9
• Gene Symbols: DMTN
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Dematin.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2039
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG