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Tocris Bioscience™ Demethylasterriquinone B1
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Catalog No. 18195
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18-195 5 mg
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Catalog No. 18-195 Supplier Tocris Bioscience™ Supplier No. 1819/5
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Description

Selective insulin RTK activator

Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Chemical Identifiers

CAS 78860-34-1
Molecular Formula C32H30N2O4

Specifications

Quantity 5 mg
Formula Weight 506.59
Purity 95%
Molecular Weight (g/mol) 506.602
Chemical Name or Material Demethylasterriquinone B1

Safety and Handling

Recommended Storage Desiccate at -20°C
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