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Invitrogen™ DENND1B Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA521824
Description
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain. Predicted reactivity: Mouse (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Clathrin (see MIM 118955)-mediated endocytosis is a majormechanism for internalization of proteins and lipids. Members ofthe connecdenn family, such as DENND1B, function as guaninenucleotide exchange factors (GEFs) for the early endosomal smallGTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptorprotein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35activation with the clathrin machinery.
Specifications
DENND1B | |
Polyclonal | |
Unconjugated | |
DENND1B | |
4632404N19Rik; 4930467M19Rik; 6820401H01Rik; ASL1/9AS1-1 fusion; C1ORF18; C1orf218; Connecdenn 2; DENN domain containing 1B; DENN domain-containing protein 1B; DENN/MADD domain containing 1B; Dennd1b; F730008N07Rik; Fam31b; family with sequence similarity 31, member B; Protein FAM31B; RP11-53I24.2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
163486, 329260 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunocytochemistry | |
0.9 mg/mL | |
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
Q3U1T9, Q6P3S1 | |
DENND1B | |
Recombinant protein encompassing a sequence within the center region of human DENND1B. The exact sequence is proprietary. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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