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Invitrogen™ DENND3 Polyclonal Antibody
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Catalog No. PIPA564996
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100 μL
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Catalog No. Quantity
PIPA564996 100 μL
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Catalog No. PIPA564996 Supplier Invitrogen™ Supplier No. PA564996
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PTSFLMGCHLD HFEEVSKEAD GLVLINIDHG SITYSKSTDD NVDIPDVPLL AAQTFIQRVQ SLQLHHELHA AHLLSSTDLK EGRAHRRSWQ QKLNCQIQQT T Highest antigen sequence identity to the following orthologs - mouse 81%, rat 78%.

Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen DENND3
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DENND3
Gene Accession No. A2RUS2
Gene Alias AI447457; DENN domain containing 3; DENN domain-containing protein 3; DENN/MADD domain containing 3; Dennd3; E030003N15Rik; KIAA0870
Gene Symbols DENND3
Host Species Rabbit
Immunogen Recombinant Human DENND3. Recombinant protein control fragment (Product #RP-105756).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22898
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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