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Invitrogen™ DERL1 Polyclonal Antibody
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Catalog No. APPA6598
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100 μL
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APPA6598 100 μL
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Catalog No. APPA6598 Supplier Invitrogen™ Supplier No. PA116598
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with xenopus, bovine, chicken, rat, zebrafish, and mouse based on 100% sequence homology. Suggested positive control: antigen standard for DERL1 (transient overexpression lysate), KRM (canine microsome) lysates.

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DERL1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Phosphate, tris citrate with 0.1% sodium azide; pH 7-8
Gene DERL1
Gene Accession No. Q99J56, Q9BUN8
Gene Alias 1110021N07Rik; AI195141; AW551338; Degradation in endoplasmic reticulum protein 1; DER1; DER-1; Der1-like domain family, member 1; der1-like protein 1; Derl1; derlin 1; derlin-1; DERtrin-1; RGD1311835; UNQ243/PRO276
Gene Symbols DERL1
Host Species Rabbit
Immunogen A synthetic peptide made to the C-terminal region of human Derlin 1 (between residues 200-251).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103158862, 475086, 67819, 79139
Target Species Human, Mouse, Canine, Hamster
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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