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Invitrogen™ DERL1 Polyclonal Antibody
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Catalog No. PIPA553444
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100 μL
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PIPA553444 100 μL
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Catalog No. PIPA553444 Supplier Invitrogen™ Supplier No. PA553444
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LMFRYPMDLG GRNFLSTPQF LYRWLPSRRG GVSGFGVPPA SMRRAADQNG GGGRHNWGQG FRLGDQ Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen DERL1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene DERL1
Gene Accession No. Q9BUN8
Gene Alias 1110021N07Rik; AI195141; AW551338; Degradation in endoplasmic reticulum protein 1; DER1; DER-1; Der1-like domain family, member 1; der1-like protein 1; Derl1; derlin 1; derlin-1; DERtrin-1; RGD1311835; UNQ243/PRO276
Gene Symbols DERL1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human DERL1. Recombinant protein control fragment (Product #RP-91209).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79139
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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